他的手探进她花蕊里

中西秀树

职称：professor, Doctoral supervisor

学历/学位：Postgraduate/ Doctor

电话：18921391657

电子邮箱：hideki@jiangnan.edu.cn

多年来以酵母细胞及哺乳动物细胞为研究对象，主要从事分子生物学，生物化学以及细胞遗传学等领域的研究。酿酒酵母是良好的真核模式细胞，既具有微生物的特征，又保持着与哺乳动物细胞相似的基本生理过程。目前，团队致力于在酿酒酵母中重新构建哺乳动物细胞的突触小泡融合研究体系、O-GlcNAc糖基化修饰系统的研究，为疾病发生的相关基因的溯源及疾病治疗药物的筛选提供良好的高通量筛选体系。此外，利用酿酒酵母营养态细胞和孢子结构的独特性，研发其作为载体在酶胶囊、药物传递、口服疫苗乃至功能食品等领域的应用技术。

他的手探进她花蕊里:

学习工作经历（自本科填起）：

教育经历

1998.4-2001.3 日本 东京农工大学  博士学位

1996.4-1998.3 日本 东京农工大学  硕士学位

1992.4-1996.3 日本 东京农工大学  学士学位

工作经历：

2011.5-至今   江南大学生物工程他的手探进她花蕊里 教授

2007.7-2011.5 日本 福岛县立医科大学 助理教授

2006.7-2007.6 日本 国立产业合研究所（AIST）糖锁研究中心 助理研究员

2001.7-2006.6 美国 纽约州立大学 研究员

2001.4-2001.6 日本 产业技术综合研究所 博士后研究员

他的手探进她花蕊里:EDUCATION

Ph. D. 2001      Tokyo University of Agriculture and Technology, Tokyo, Japan.

M. Sc. 1998     Tokyo University of Agriculture and Technology, Tokyo, Japan

B. Sc. 1996      Tokyo University of Agriculture and Technology, Tokyo, Japan

PROFESSIONAL EXPERIENCE

2011 Jul. -                Professor

                                 Jiangnan University

                                 Wuxi, China

2009 Oct.                 Assistant Professor

        -2011 Mar.        Fukushima Medical University

                                 Fukushima, Japan

2007 Jul.                  Postdoctoral Research fellow

        -2009 Sep.        Fukushima Medical University (Dr. Ikuo Wada Lab)

                                 Fukushima, Japan

2006 Jul.                  Postdoctoral Research Scientist (Dr. Shinichiro Nishimura   

        -2007Jun.         Lab)

                                 Drug-Seeds Discovery Research Laboratory

                                 National Institute of Advanced Industrial Science    

                                 and Technology

                                 Sapporo, Japan

2001 Jul.                  Postdoctoral Associate (Aaron Neiman Lab)

       -2006 Jun.         Department of Biochemistry and Cell Biology

                                 State University of New York at Stony Brook

                                 Stony Brook, NY

2001 Apr.-Jun.         Postdoctoral Research Scientist (Yoshifumi Jigami Lab)

                                 Institute of Molecular and Cell Biology

                                 National Institute of Advanced Industrial Science

                                 and Technology

                                 Tsukuba, Japan

一、论文（论著）发表情况

部分代表性论文如下：

1. Shao K, Li F, Yang Y, Wang N, Gao X-D*, Nakanishi H*. Characteristics of SNARE proteins are defined by distinctive properties of SNARE motifs. (2020) Biochimica et Biophysica Acta (BBA) - General Subjects. 1864(10):129658.

2. Basiony M, Yang Y, Liu G, Gao X-D*, Nakanishi H*. Studies on the properties of the sporulation specific protein Dit1 and its product formyl tyrosine. (2020) Journal of Fungi. 6(2): 77.

3. Jin Y, Okamoto M, Chibana H, Liu G, Gao X-D*, Nakanishi H*. Functional characteristics of Svl3 and Pam1 that are required for proper cell wall formation in yeast cells. (2020) Yeast. 37(7-8): 359-371.

4. Liu X, Li Z, Chen Z, Wang N, Gao Y, Nakanishi H*, Gao X-D*. Production of L-ribulose using an encapsulated L-arabinose isomerase in yeast spores. (2019) Journal of Agricultural and Food Chemistry. 67(17): 4868-4875. 

5. Shao K, Wang Q, Wang N, Gao X-D*, Nakanishi H*. Construction of functional chimeras of syntaxin-1A and its yeast orthologue, and their application to the yeast cell-based assay for botulinum neurotoxin serotype C. (2019) Biochimica et Biophysica Acta (BBA) - General Subjects. 1863(11):129396.

6. Feng S, Zhang H, Xu S, Zhi C, Nakanishi H*, Gao X-D*. Folate-conjugated, mesoporous silica functionalized boron nitride nanospheres for targeted delivery of doxorubicin. (2019) Materials Science & Engineering C-Materials for Biological Applications. 96:552-560.

7. Liu X, Li Z, Chen Z, Wang N, Gao Y, Nakanishi H*, Gao X-D*. Production of L-Ribulose Using an Encapsulated L-Arabinose Isomerase in Yeast Spores. (2019) Journal of Agricultural and Food Chemistry. 67: 4868-4875.

8. Feng S, Zhang H*, Zhi C, Gao X-D, Nakanishi H*. pH-responsive charge-reversal polymer-functionalized boron nitride nanospheres for intracellular doxorubicin delivery. (2018) International Journal of Nanomedicine. 13: 641-652.

9. Bemena LD, Mukama O, Wang N, Gao X-D*, Nakanishi H*. Characterization of a yeast sporulation-specific P450 family protein, Dit2, using an in vitro assay to crosslink formyl tyrosine. (2018) The Journal of Biochemistry. 163: 123-131.

10. Pan H-P, Wang N, Tachikawa H, Nakanishi H*, Gao X-D*. β-1,6-glucan synthesis-associated genes are required for proper spore wall formation in Saccharomyces cerevisiae. (2017) Yeast. 34: 431-446.

11. Bemena LD, Mukama O, Neiman AM, Li Z, Gao X-D, Nakanishi H*. In vitro reconstitution of the yeast spore wall dityrosine layer to disclose the mechanism of its assembly. (2017) Journal of Biological Chemistry. 292: 15880-15891.

12. Nakanishi H*, Li F, Han B, Arai S, Gao X-D*. Yeast cells as an assay system for in vivo O-GlcNAc modification. (2017) Biochimica et Biophysica Acta (BBA) - General Subjects. 1861: 1159-1167.

二、专利情况

1. 中西秀树，高晓冬，张海妮，李子杰

一种以酿酒酵母孢子为载体的新型固定化酶的制备方法. ZL201310422568.8，授权

三、承担教学科研项目情况

1、国家自然科学基金面上项目(32071467)：临床和商业应用有益的肉毒毒素的筛选。

2、国家自然科学基金面上项目(21576118)：酿酒酵母孢子新型微球的制备及应用研究。

四、获奖情况

1、2012年 无锡市“社会事业领军人才计划”

2、2013年 江苏省“双创计划 高层次创新创业人才引进计划”

3、2013年 江苏省“创新团队计划”

以上资料更新时间截止：2021年9月